Untold Stories of the E.R.: Extra Dose is a series that airs Extended Enhanced Episodes with extra information and unseen footage from the show "Untold Stories of the E.R." that also airs on TLC.
Runtime: 60 minutes
Untold Stories of the E.R.: Extra Dose - Hemolytic disease of the newborn - Netflix
Hemolytic disease of the newborn, also known as hemolytic disease of the fetus and newborn, HDN, HDFN, or erythroblastosis fetalis, is an alloimmune condition that develops in a peripartum fetus, when the IgG molecules (one of the five main types of antibodies) produced by the mother pass through the placenta. Among these antibodies are some which attack antigens on the red blood cells in the fetal circulation, breaking down and destroying the cells (hemolysis). The fetus can develop reticulocytosis and anemia. This fetal disease ranges from mild to very severe, and fetal death from heart failure (hydrops fetalis) can occur. When the disease is moderate or severe, many erythroblasts (immature red blood cells) are present in the fetal blood, and so these forms of the disease can be called erythroblastosis fetalis (or erythroblastosis foetalis). HDFN represents a breach of immune privilege for the fetus or some other form of impairment of the immune tolerance of pregnancy. Various types of HDFN are classified by which alloantigen provokes the response. In order of incidence, the types include ABO, anti-RhD, anti-RhE, anti-Rhc, anti-Rhe, anti-RhC, multiantigen combinations, and anti-Kell.
Untold Stories of the E.R.: Extra Dose - Complications - Netflix
Complications of HDN could include kernicterus, hepatosplenomegaly, inspissated (thickened or dried) bile syndrome and/or greenish staining of the teeth, hemolytic anemia and damage to the liver due to excess bilirubin. Similar conditions include acquired hemolytic anemia, congenital toxoplasma, congenital syphilis infection, congenital obstruction of the bile duct, and cytomegalovirus (CMV) infection. High at birth or rapidly rising bilirubin Prolonged hyperbilirubinemia Bilirubin Induced Neurological Dysfunction Cerebral Palsy Kernicterus Neutropenia Thrombocytopenia Hemolytic anemia - Must NOT be treated with iron Late onset anemia - Must NOT be treated with iron. Can persist up to 12 weeks after birth.
Untold Stories of the E.R.: Extra Dose - References - Netflix